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Biochemistry and Genetics of Yeasts: Pure and Applied Aspects consists of papers presented at a symposium organized by the Academia Brasileira de Ciencias held at the Universidade de Sao Paulo, on December 4-10, 1977. Organized into seven parts, this book reveals relevant and exciting developments in the areas of yeast genetics, respiration and fermentation, metabolic regulation, cell wall structure, synthesis of macromolecules, and transport. It demonstrates the presence of great progress in the knowledge of structure and functions of the yeast mitochondrial DNA. This book will be useful to scientific institutes and university laboratories interested in the biochemistry, genetics, and technology of yeasts.

Biochemistry and Physiology of Nutrition, Volume II focuses on the processes, methods, and studies on nutrition. The book starts by discussing intracellular localization through histochemical methods of enzymes and vitamins; the structural changes in vitamin deficiency; and microbiology of digestion. Deficiencies in vitamins, A, C, D, E, B1, riboflavin, nicotinic acid, choline, biotin, and folic acid are noted. The book then focuses on microbiology of digestion, considering the establishment of microbial population in the alimentary tract, results of microbial digestion, antibiotics, and intestinal flora of man. The text also defines the nutrition system of worms, insects, and protozoa. The generation of ATP in terminal respiration and anaerobic glycolysis, as well as ATP’s role in energy transfer, is noted. The discussions also focus on hydrolytic and phosphorylitic enzymes, such as carbohydrates, esterases, amidases, phosphatases, and phosporylases. Other topics covered are respiratory enzymes and coenzymes in which nucleotides, glucose diphosphate, diphosphoglyceric acid, and thiamine pyrophosphate are noted. The book notes the functions of iron compounds in the body, particularly in blood and tissues, and then touches on calcium and phosphorus metabolism. Given considerations are calcium and phosphorus in blood, skeletal calcium and phosphorus, and the factors affecting adsorption. A discussion also focuses on trace elements and the effects of protein, carbohydrates, fats, and vitamins in nutrition. The book is a vital source of data for readers interested in studying the elements, factors, processes, and methods involved in nutrition.

Biochemistry and Physiology of Plant Immunity details the physiological properties of plant immunity from a biochemical perspective. The book provides a summary and concise explanation of the various studies conducted on the field of biochemistry and physiology of plant immunity. The text first details the evolution of parasitism, and then proceeds to discussing the biochemistry and physiology of heterotrophic micro-organisms. Next, the selection talks about the biochemistry and physiology of diseased plant, before it finally deals with plant immunity. The book will be of great use to researchers and practitioners of disciplines that deal with the health of vegetation, such as botany and horticulture.

LABFAX volumes are purpose-designed data reference books for practising scientists. Each book presents key information for a major subject in one place and so saves hours of searching. It does not simply collect together data which are already available in catalogues since these are often incomplete and can contain conflicting information. Rather, the authors and editors of each LABFAX volume have searched the original literature for the accurate data which they know the specialist needs.Biochemistry LabFax is a detailed compendium of essential information – on radioisotopes, enzymes, proteins, nucleic acids, lipids, plus data on selected techniques such as chromatography, electrophoresis, etc. – needed on an almost daily basis by researchers in any area of biochemistry. In addition, the book acts as a gateway to other sources for information more specific than can be covered in a volume of this size.

Biochemistry of Brain is a collection of articles dealing with the developments in the biochemistry of the brain. This book gives a comprehensive and critical discussion of important developments in studies concerning the above subject. This text discusses the structure, function, and metabolism of glycosphingolipids, which are related to the study of sphingolipid storage diseases. Inborn defects of metabolism are found in Gaucher’s and Fabry’s disease, which are characterized by lipid accumulation in the brain. Another paper reviews the chemical and genetics of critically lysosomal hydrolase deficiencies that can cause the storage of sphingolipids. This book then explains the role of myelin basic protein in lipids in vivo that the weak bonding of the protein is not a major component of myelin stability. Another paper discusses the procedures for isolating subfractions of myelin and myelin-related membranes, with some attention given on the alterations in the subfractionation of myelin in pathological hypomyelinating and demyelinating conditions. Another article discusses the biochemical and enzymatic composition of lysosomes and the biosynthesis, intracellular transport, storage, and the degradation of lysosomal constituents. This collection of papers will benefit scientists doing research in microbiology, microchemistry, molecular genetics, and neurochemistry.

“Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Key Features. Provides a comprehensive introduction to collagen and structural proteins. Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation. Includes a chapter dedicated to the biomarkers of structural proteins. Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states”

Biochemistry of Foods attempts to emphasize the importance of biochemistry in the rapidly developing field of food science, and to provide a deeper understanding of those chemical changes occurring in foods. The development of acceptable fruits and vegetables on postharvest storage is dependent on critical biochemical transformations taking place within the plant organ. The chapters discuss how meat and fish similarly undergo postmortem chemical changes which affect their consumer acceptability. In addition to natural changes, those induced by processing or mechanical injury affect the quality of foods. Such changes can be controlled through an understanding of the chemical reactions involved, for instance, in enzymic and nonenzymic browning. Increased sophistication in food production has resulted in the widespread use of enzymes in food-processing operations. Some of the more important enzymes are discussed, with an emphasis on their role in the food industry. The final chapter is concerned with the biodeterioration of foods. The various microorganisms involved in the degradation of proteins, carbohydrates, oils, and fats are discussed, with special reference to the individual biochemical reactions responsible for food deterioration.

Biochemistry of Human Cancer focuses on advances in the application of biochemistry to the study of human cancers, such as neoplastic immunoglobulinopathies, cancer of the bladder, tumors of the neural crest, leukemias and lymphomas, and neoplasms of the bone. It also examines certain features of human cancer ranging from general metabolic characteristics to enzymic aspects and immunochemical considerations. Organized into 18 chapters, this book begins with an overview of the general metabolic features of cancer, with emphasis on the metabolism of lipids, proteins, and carbohydrates. It then discusses the important biochemical aspects of pulmonary and prostatic neoplasms, including the serum acid and alkaline phosphatase activities of prostatic carcinoma. The remaining chapters look at the role of enzymes and immunoglobulins in cancer, the tryptophan metabolism in cancer of the bladder and the carcinoid syndrome, the link between amino acid metabolism and tumors of the neural crest, and the neoplasms of the digestive tract and the accessory organs (pancreas and liver). The book explains the metabolism of purines and pyrimidines in cancer, hypercalcemia in neoplastic disease without evidence of bone metastases, and neoplasms of other organs, such as the pituitary gland, thyroid, testis, and adrenal cortex. Brief case reports from the literature are included to illustrate correlations between biochemical and clinical findings. Scientists, biochemists, and clinical investigators concerned with the biochemistry of human cancer will find this book highly informative.

Biochemistry of Insects reviews the state of knowledge in insect biochemistry. The book begins by examining the function of carbohydrates in regulating and maintaining the life processes of insects. This is followed by separate chapters on the functional roles of lipids and proteins in insects; and protein synthesis in insects. Subsequent chapters cover the chemistry of insect cuticle; the structure, distribution, and chemistry of insect biochromes; and chemical control of insect behavior. Also discussed are the biochemical aspects of the natural products used by insects in defensive contexts; the reaction of insecticides and related compounds with their targets; detoxification mechanisms in insects; and genetic variation in natural populations. Designed to serve as a basic textbook in field, this volume should be equally useful as an auxiliary text for most relevant courses in insect biology, particularly insect physiology, insect ecology, insect control, and economic entomology. The book should also serve as an important reference source for the advanced student, the research scientist, and the professional entomologist seeking authoritative details of relevant areas of subject matter.

“Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. Key Features. Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry. References from current literature will be included in each chapter to facilitate more in-depth study. Key concepts are supported by figures and models to improve reader understanding. Chapters provide historical perspective and current analysis of each topic”

The Biochemistry of Plants: A Comprehensive Treatise, Volume 11: Biochemistry of Metabolism provides information pertinent to the chemical and biochemical aspects of metabolism. This book discusses the control mechanisms of metabolism. Organized into nine chapters, this volume begins with an overview of the history of biochemistry and discusses the developments in the kinetics of regulatory enzymes. This text then examines a theory that explains how subunit interactions modulate the rate of conversion of a substrate into a product. Other chapters consider some relation between cell-wall elongation and cell-wall charge density and explore the subcellular localization of the enzymes of glycolysis. This book discusses as well the regulation of glycolysis and the pentose phosphate pathway. The final chapter deals with the pathways of C1 metabolism that are of prime importance, as the synthesis of several cellular constituents depends directly or indirectly on folate metabolism. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.

Biochemistry of Platelets is a comprehensive review of the biochemistry of platelets, with emphasis on the molecular basis for the various biological processes in which they participate. Topics range from stimulus-response coupling mechanisms to platelet contractile proteins, platelet membrane glycoproteins, and storage organelles in platelets and megakaryocytes. The expression and function of adhesive proteins on the platelet surface is also discussed. Comprised of 12 chapters, this book begins with a description of the morphological and metabolic responses to agonists, as well as the involvement of certain processes in the coupling of agonist-receptor interactions to platelet responses. The following chapter deals with platelet arachidonate metabolism and platelet-activating factor, focusing on the release of arachidonate from platelet lipid stores; pathways of platelet arachidonate metabolism and effects of arachidonate metabolites; and inhibition of platelet arachidonate metabolism by aspirin. The structure, function, and modification in disease of platelet membrane glycoproteins are then discussed, along with prothrombin activation on platelets and platelet regulation of thrombus formation. Secreted platelet proteins as markers for pathological disorders are also considered. This monograph is intended as a reference for investigators involved in platelet research as well as a source of information for those working in other areas of biological investigation.

This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.

“A readable introduction to this difficult topic, this textbook provides information on the molecular structures and biochemical events that occur in the eye. With specific clinical examples, basic science is linked to clinical practice and helps students understand this challenging topic.General biochemistry is discussed in each chapter. Many examples of biochemical pathology and disease processes, such as age-related cataract formation and ocular diabetes, are described. Key Features. Well-illustrated content, featuring color inserts with 10 illustrations, shows visual aspects of biochemistry.. Each chapter features a general review of the subject matter prior to discussing ocular biochemistry.. Discussions of proteins that are either unique to the eye and/or have special functions in the eye, such as collagen’s role in the structure of the cornea, emphasize the importance of these compounds and their many essential cellular and ocular functions.. Discussions of the nature and function of enzymes, in addition to descriptions of examples of specific enzymes found in the eye, highlight the manner in which many biochemical reactions occur in the eye is via enzyme catalysis.. A chapter on carbohydrates emphasizes the importance of the two roles of carbohydrates in ocular tissue: energy supply (nutrition) and as a source of extracellular structure.. An explanation of the many different kinds of lipids that exist in the eye features the most up-to-date material on tear film lipids and useful information on dietary Vitamin A requirements.. A chapter on hormones deals with the role of hormones in general and shows how hormones play roles in ocular functions, including the process of visual transduction as a hormonal function.. A thorough review of nucleic acid chemistry points out its role in molecular biological functions such as DNA replication, RNA transcription, and protein translation, as well as DNA mutations.. A chapter on neurochemistry provides an understanding of basic neurochemistry and how neurochemistry can explain the complex functions of the retina.. The immunochemistry chapter contains basic material on biochemical and cellular immunology, discussing immune privilege in the eye and the importance of immune reactions at the anterior segment.. A new chapter describes the biochemical pathology of four degenerative conditions (corneal ulcers, chemical burns, glaucoma, and cellular apoptosis) to help the clinician understand pathological processes and the time course of degenerative processes and methods of treatment.. A new chapter on Water and Ocular Fluids offers unique coverage of the functions of eye fluids and how drug companies must design drugs for the ocular surface, comparing the physical, chemical, and biological properties of water with fluids found in the eye.”

Biochemistry of the Glycosidic Linkage: An Integrated View is a collection of papers presented at The Pan-American Association of Biochemical Societies Symposium, held in San Carlos de Bariloche, Argentina on November 8-11, 1971. This symposium is organized as a tribute to Luis F. Leloir and his contributions in the field glycosidic linkage. This book is divided into six sessions encompassing 57 chapters. The opening session discusses the role of biochemical mechanisms in the glycosidic linkage formation. The following sessions examine the metabolic functions of some disaccharides, such as trehalose, sucrose, glucose, and starch. These sessions also look into the biosynthesis, function, and properties of carbohydrates containing polymers. The discussion then shifts to the control of enzyme biosynthesis involved in the glycosidic linkage metabolism, with particular emphasis on alpha-amylase, lactose synthetase, phosphorylase, and neuraminidase enzymes. Another session is devoted to the regulatory mechanisms and control of glycogen metabolism. The concluding session covers the genetic analysis and biochemical characterization of the enzymes involved in the glycosidic linkage metabolism. Biochemists and carbohydrate researchers will find this text invaluable.