Life Science

A Handbook of Clinical Genetics focuses on clinical genetics and the growing demand for genetic counseling. This book begins by introducing issues regarding changes in morbidity and mortality; fall in birth rate; advances in technology and treatment; and complex social changes. Other topics covered include genetic and environmental factors in disease; the genetic code; pedigree information; inheritance patterns; genetic counseling; prenatal diagnosis of genetic disease; special problems; and ethical issues and future developments. The last portion of this text is devoted to a glossary of unfamiliar medical terms, list of recommended books for further research and study, and appendices consist of a case on genetic counseling for Down's syndrome. This handbook is suitable for nurses, medical students, and doctors needing an introduction to clinical genetics.

Advances in Physiological Sciences, Volume 20: Advances in Animal and Comparative Physiology covers the proceedings of the symposia of the 28th International Congress of Physiology. The book discusses several studies that tackle issues about the advances in animal and comparative study. The text is comprised of 61 chapters in which Chapter 4 and the succeeding chapters are grouped into eight parts based on the topic of the studies. The opening chapter explains sensory modalities beyond human perception, while Chapter 2 discusses trends in the physiology of domesticated animals. Chapter 3 reviews muscles in living animals, which is followed by topics grouped into parts. The first part deals with fetal homeostasis, while the second part discusses control of corpora lutea function of ruminant and non-ruminant domesticated animals. The third part deals with the comparative physiology of lactation in farm animals, while the fourth part tackles digestion in non-ruminant herbivorous animals. Parts 5 and 6 cover topic on diving, which includes metabolism, physiology, and control. The seventh part discusses phylogenesis of hormones and hormone receptors, and the last part covers neuromuscular transmission in invertebrates. Researchers whose line of work concerns the physiological properties of animals will find this book as a great source of related literatures.

Advances in Gene Technology: Molecular Genetics of Plants and Animals contains the proceedings of the Miami Winter Symposium held in January 1983 in Miami, Florida. The papers explore advances in the molecular genetics of plants and animals and cover a wide range of topics such as genetic manipulation of plants; plant cell cultures, regeneration, and somatic cell fusion; and nitrogen fixation. Practical applications of gene technology with plants are also discussed. Comprised of 84 chapters, this volume begins with an overview of how plants manufacture from carbon dioxide and water all of their substances, paying particular attention to the path of carbon in photosynthesis. The organization of the plant genome is then considered, along with techniques for cell culture, regeneration, and somatic cell fusion; vector systems; and nitrogen fixation. Some chapters focus on gene transfer by protoplast fusion; somatic cell genetic systems in corn; regulation of transcription of the nitrogen fixation operons; and leghemoglobin and nodulin genes of soybean. The final section is devoted to practical applications of gene technology to plants and to technology frontiers in animal biology, in particular embryonic development and vaccines and diagnostic methods for animal diseases. This book should be of value to molecular geneticists.

Amino Acids, Proteins, and Cancer Biochemistry focuses on the contributions of Jesse P. Greenstein to biological chemistry, including kinetics, protein mixtures, metabolism, tumors, and biosynthesis. The selection first offers information on quantitative nutritional and in vivo metabolic studies with water-soluble, chemically defined diets and internal hydrogen bonding in ribonuclease. Discussions focus on the effects of deuterium on transition temperature, kinetics of deuterium-hydrogen exchange, applications of chemically denned diets, formulation of water-soluble, chemically defined diets, and large-scale preparation of optically pure amino acids. The manuscript then examines the chromatographic evaluation of protein mixtures and observations on the activation of amino acids and biosynthesis of peptide bonds, including synthesis of phenylacetylglutamine and benzoylglycine, studies on amino acyl adenylates, and synthesis of glutamine. The publication ponders on free amino acids and related substances in normal and neoplastic tissues; nucleic acids of normal tissues and tumors; and carbohydrate metabolism in ascites tumor and HeLa cells. Topics include carbohydrate metabolism of ascites tumor cells, comparative biochemistry of glycolysis, DNA and the genetic concept of cancer, and constancy of free amino acid patterns of tissues. The selection is a valuable source of data for biochemists and researchers interested in amino acids, proteins, and cancer biochemistry.

The advent of biotechnology has the potential to develop a variety of novel or better quality products for the treatment of a large number of diseases in livestock. In addition, as we understand more about the reproductive physiology of animals, the potential exists to dramatically increase the productivity of animals through better therapeutics and diagnostics for the control of many infectious diseases. Productivity can also be increased through animal breeding strategies including gene transfer, micromanipulation of embryos and gamete sex selection. As well as being a valuable reference to current knowledge in these areas, this first supplement toComprehensive Biotechnologyalso looks at societal concerns over the use of antibiotics and chemical residues in meat and milk products, which are forcing biotechnologists to investigate more natural means of controlling infection by stimulating the animal's own immune system to combat infection. The identification of a variety of cytokines which are involved in regulating immune responses provides opportunities to use the animal's natural defence mechanisms to combat many infections or increase the animal's resistance to such infections. These approaches should provide tools for eventual elimination of specific diseases from counties, regions or whole continents.

There has been a dramatic increase in the perception of the value of animal cell biotechnology to the research and manufacturing communities in recent years. This volume seeks to keep the reader up-to-date with this progress. This sixth and final volume in the series concentrates on the biology of animal cells in culture, giving special attention to the relationship between biology and the ability to use such cells productively. As the search continues for greater productivity, there is a need to understand the switches within cells that control expression. Additional abilities to manipulate those switches in a controllable manner are also required. In the last five years, considerable progress has been made in the elucidation of the mechanisms for cell signaling and control of gene expression. The 13 chapters of this volume are devoted to these subjects and to techniques in areas of particular concern in manufacturing circles. The achievements in the field to date are described in this book, which, together with its five companion volumes in the series, will provide a building block for the future development of animal cell biotechnology.

Animal Cell Technology: Products of Today, Prospects for Tomorrow is a collection of papers that discusses the advancement and future of biotechnology. The book presents a total of 164 materials that are organized into 22 sections. The coverage of the text includes the various methodologies involved in animal cell technology, such as post translational modifications; kinetics and modeling; and measurement and assay. The book also covers product safety and consistency testing; products from animal cells in culture; and apoptosis and cell biology. The text will be of great use to biologists, biotechnicians, and biological engineers. Readers who have an interest in the advancement of biotechnology will also benefit from the book.

Animal Virus Genetics is a collection of scientific presentations of the ICN-UCLA Symposia on Molecular and Cellular Biology, held at the University of California, Los Angeles in 1980. The papers in the compendium focus on the basic genetic model systems; the uses of genetic approaches to study basic problems in molecular biology; and on the increasing application of genetic systems to the study of more complex viral-host interactions such as viral virulence and persistence. Microbiologists, cellular biologists, and virologists will find the book insightful.

Animals and Environmental Fitness, Volume 1: Invited Lectures is a collection of papers that tackles ecological concerns. The materials of the book are organized according the main issue of their contents. The text first tackles the chemical factors of the environment, such as water and oxygen availability, ecomones, and pollutants. The other half of the book encompasses the physical factors of the environment that include light, pressure, and temperature. The text will be of great use to scientists who study the interaction between flora, fauna, and the total environment.

Applied Biochemistry and Bioengineering, Volume 2: Enzyme Technology discusses the industrial applications of immobilized enzymes. Organized into 10 chapters, this volume first describes the techniques for the isolation and purification of intracellular and extracellular enzymes for use on an industrial scale. It then deals with immobilized enzyme processes, with an emphasis on immobilized glucose isomerase and the amylolytic enzymes related to the production of high-fructose syrups from starch. Significant topics on immobilized enzyme technology for future uses in energy transduction and in pharmaceutical modifications of steroid compounds are also explored. Microbiologists, geneticists, and chemical engineers will find this book of great value.

"Applied plant genomics and biotechnology reviews the recent advancements in the post-genomic era, discussing how different varieties respond to abiotic and biotic stresses, investigating epigenetic modifications and epigenetic memory through analysis of DNA methylation states, applicative uses of RNA silencing and RNA interference in plant physiology and in experimental transgenics, and plants modified to produce high-value pharmaceutical proteins. The book provides an overview of research advances in application of RNA silencing and RNA interference, through Virus-based transient gene expression systems, Virus induced gene complementation (VIGC), Virus induced gene silencing (Sir VIGS, Mr VIGS) Virus-based microRNA silencing (VbMS) and Virus-based RNA mobility assays (VRMA); RNA based vaccines and expression of virus proteins or RNA, and virus-like particles in plants, the potential of virus vaccines and therapeutics, and exploring plants as factories for useful products and pharmaceuticals are topics wholly deepened. The book reviews and discuss Plant Functional Genomic studies discussing the technologies supporting the genetic improvement of plants and the production of plant varieties more resistant to biotic and abiotic stresses. Several important crops are analysed providing a glimpse on the most up-to-date methods and topics of investigation. The book presents a review on current state of GMO, the cisgenesis-derived plants and novel plant products devoid of transgene elements, discuss their regulation and the production of desired traits such as resistance to viruses and disease also in fruit trees and wood trees with long vegetative periods. Several chapters cover aspects of plant physiology related to plant improvement: cytokinin metabolism and hormone signaling pathways are discussed in barley; PARP-domain proteins involved in Stress-Induced Morphogenetic Response, regulation of NAD signaling and ROS dependent synthesis of anthocyanins. Apple allergen isoforms and the various content in different varieties are discussed and approaches to reduce their presence. Euphorbiaceae, castor bean, cassava and Jathropa are discussed at genomic structure, their diseases and viruses, and methods of transformation. Rice genomics and agricultural traits are discussed, and biotechnology for engineering and improve rice varieties. Mango topics are presented with an overview of molecular methods for variety differentiation, and aspects of fruit improvement by traditional and biotechnology methods. Oilseed rape is presented, discussing the genetic diversity, quality traits, genetic maps, genomic selection and comparative genomics for improvement of varieties. Tomato studies are presented, with an overview on the knowledge of the regulatory networks involved in flowering, methods applied to study the tomato genome-wide DNA methylation, its regulation by small RNAs, microRNA-dependent control of transcription factors expression, the development and ripening processes in tomato, genomic studies and fruit modelling to establish fleshy fruit traits of interest; the gene reprogramming during fruit ripening, and the ethylene dependent and independent DNA methylation changes. Key Features. provides an overview on the ongoing projects and activities in the field of applied biotechnology. includes examples of different crops and applications to be exploited. reviews and discusses Plant Functional Genomic studies and the future developments in the field. explores the new technologies supporting the genetic improvement of plants"